Research progress on animal models of colon cancer in Traditional Chinese and Western Medicine
10.3781/j.issn.1000-7431.2024.2403-0146
- VernacularTitle:结肠癌中西医动物模型研究进展
- Author:
Yang SHEN
1
;
Guojuan WANG
;
Naicheng ZHU
;
Min GUO
;
Wenjing LIAO
;
Wenyan YU
Author Information
1. 江西中医药大学中医基础理论分化发展研究中心,江西省中医病因生物学重点实验室,江西 南昌 330004
- Publication Type:Journal Article
- Keywords:
Colon cancer;
Traditional Chinese and western medicine;
Animal model
- From:
Tumor
2024;44(11):1116-1129
- CountryChina
- Language:Chinese
-
Abstract:
Colon cancer is a common malignant tumor in the gastrointestinal tract,with morbidity and mortality rates increasing every year.Currently,the etiology of colon cancer has not been fully elucidated.With the deepening of colon cancer research and treatment,it is especially important to establish corresponding preclinical in vivo models.In the treatment of colon cancer,Chinese medicine follows the principle of diagnosis and treatment,adopts the method of supporting the positive and dispelling the evil,adjusts the body's qi and blood,and the deficiency of internal organs to maintain the balance of the body's yin and yang,so as to achieve the purpose of anti-tumor.Chinese medicine animal models of colon cancer can be broadly divided into five categories:damp-heat accumulation,qi stagnation and blood stasis,qi and blood deficiency,spleen and kidney yang deficiency and liver and kidney yin deficiency.Western animal models of colon cancer are commonly divided into 4 categories:spontaneous,induced,transplanted and genetically engineered.The paper summarizes the construction methods and characteristics of colon cancer animal models currently commonly used in Chinese and western medicine,and summarizes,analyzes and concludes the colon cancer animal models based on three aspects:how to select animal models,comparison of Chinese and western medicine modeling methods and evaluation of modeling success,with a view to finding suitable modeling methods for preclinical experiments,so as to provide guidance for the selection of animal models of colon cancer.
