Longitudinal investigation of multisymptom burden during hematopoietic reconstitution in children after hematopoietic stem cell transplantation
10.3760/cma.j.cn211501-20240622-01637
- VernacularTitle:造血干细胞移植后患儿造血重建期多症状负担的纵向调查
- Author:
Geng LIN
1
;
Jiwen SUN
;
Mengxue HE
;
Nanping SHEN
;
Chunlei HE
;
Huimin QIAN
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科，上海 200127
- Publication Type:Journal Article
- Keywords:
Child;
Hematopoietic stem cell transplantation;
Patient-reported outcome;
Symptom burden;
Longitudinal studies
- From:
Chinese Journal of Practical Nursing
2025;41(7):498-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the current status and changes of multisymptom burden during the post-transplant hematopoietic reconstruction period in children with hematopoietic stem cell transplantation, and to provide reference for the precise management of symptoms in post-transplantation children.Methods:Children aged 7-18 years who underwent hematopoietic stem cell transplantation in Shanghai Children′s Medical Centre, Shanghai Jiao Tong University School of Medicine from September 2022 to October 2023 were selected by convenience sampling method. The Pediatric Patient Reported Outcomes version of Common Terminology Criteria for Adverse Events was used to assess multiple symptoms and burden during the reconstruction period on days 0, 7, 14, and 21 after transplantation.Results:Finally, 90 children who underwent hematopoietic stem cell transplantation were investigated, including 61 males and 29 females, aged (9.98 ± 2.96) years old. On days 0, 7, 14, and 21 after transplantation, the number of symptoms, severity of symptoms, degree of symptom interference were 20.00 (14.00), 18.00 (14.50), and 10.00 (9.75), with scores of 0.18 (0.30), 0.14 (0.29), 0.08 (0.13), 0.00 (0.08), and 0.27 (0.42), 0.19 (0.30), 0.09 (0.16), 0.03 (0.11), respectively. The overall differences were statistically significant ( Z=101.69, 93.70, 96.65, all P<0.01). The symptom burden in children showed four different trajectories including higher symptom burden in the early stages and lower in the later stages, consistently high burden, high symptom burden followed by low symptom burden, and consistently low burden. Conclusions:Children after hematopoietic stem cell transplantation are plagued by multiple symptoms during hematopoietic reconstruction, and with the treatment and time, different symptoms show different trajectories of change. Healthcare professionals should accurately assess the symptomatic changes of children after transplantation and provide targeted interventions to reduce the symptomatic burden and promote the recovery of children.
