Study of the curative effect of hemodialysis combined with hemoperfusion in treating chronic renal failure and the effect of that on the expression level of serum inflammatory cytokines
10.3969/j.issn.1672-8270.2025.02.016
- VernacularTitle:血液透析联合血液灌流治疗慢性肾衰竭的疗效及对血清炎性因子表达水平的影响
- Author:
Li MA
1
;
Wenjun YANG
1
;
Bing MA
1
;
Li ZHANG
1
Author Information
1. 新疆医科大学第一附属医院肾病三科 乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
Hemoperfusion;
Chronic renal failure;
Pro-inflammatory factor;
Anti-inflammatory factor;
Serum CD16
- From:
China Medical Equipment
2025;22(2):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the curative effect of hemodialysis combined with hemoperfusion in treating chronic renal failure and the effect of that on the expression level of serum inflammatory cytokine of patients.Methods:A total of 100 patients with chronic renal failure who admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2021 to June 2023 were selected,and they were divided into control group(50 cases who received with hemodialysis treatment)and study group(50 cases who received hemodialysis combined with hemoperfusion)according to different treatment methods of blood purification.The overall efficiency rates of the treatment of two groups were compared.The expression levels of pro-inflammatory cytokines[interleukin-6(IL-6)and interleukin-17(IL-17)]and the interleukin-10(IL-10)of anti-inflammatory cytokine,as well as β2-microglobulin(β2-MG),parathyroid hormone(PTH)and serum CD16,were monitored before and after treatment.The incidence rate of adverse reaction at the end of treatment was also recorded.Results:The overall efficiency rates of the treatment of control group and study group were 84.00%and 96.00%,and the overall efficiency rate of study group was significantly higher than that of control group(x2=4.000,P<0.05).After treatment,both groups showed decrease in pro-inflammatory cytokines(IL-6 and IL-17),and increase in anti-inflammatory cytokine(IL-10).The IL-6 and IL-17 levels of study group were lower than those of control group,and the IL-10 level of study group was higher than that of control group,and the differences of them between two groups were significant(t=8.835,4.138,9.196,P<0.05),respectively.Compared with β2-MG,PTH and CD16 after treatment in control group,the β2-MG and PTH levels in study group were lower,and the CD16 level of study group was higher,and the differences of them between two groups were significant(t=10.076,15.336,2.050,P<0.05),respectively.The overall incidence rates of adverse reaction of control group and study group were respectively 18.00%and 4.00%,and the overall incidence rate of adverse reaction of study group was significantly lower than that of control group,with statistically significant difference(x2=4.000,P<0.05).Conclusion:The treatment of hemodialysis combined with hemoperfusion can improve the curative efficiency for patients with chronic renal failure,and inhibit the levels of serum pro-inflammatory cytokines and macromolecules(β2-MG and PTH),and regulate the levels of anti-inflammatory cytokines and CD16,and reduce the incidence of adverse reaction.
