Chemical constituents from Fomes officinalis and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2025.01.017
- VernacularTitle:阿里红化学成分及其抗炎活性研究
- Author:
Subinuer JULAITI
1
;
Zhan-ming XU
;
Xuan-lin LIU
;
Lei-ling SHI
;
Xing-wang GAO
;
Xiong-fei GUO
Author Information
1. 新疆大学生命科学与技术学院,新疆乌鲁木齐 830017;新疆维吾尔自治区中药民族药研究所,新疆乌鲁木齐 830002
- Publication Type:Journal Article
- Keywords:
Fomes officinalis(Vill.ex Fr.)Ames;
chemical constituents;
isolation and identification;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2025;47(1):108-117
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Fomes officinalis(Vill.ex Fr.)Ames and their anti-inflammatory activities.METHODS The 95％ethanol extract from F.officinalis was isolated and purified by silica gel,Sephadex LH-20,HW-40C,MCI and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities in vitro were evaluated by RAW264.7 model.RESULTS Twenty compounds were isolated and identified as asperginine A(1),laricinolic acid(2),methoxylaricinolic acid(3),fomeffic acid(4),19-acetoxy-13S-hydroxylabda-8(17),14-diene(5),bisbenzopyran(6),lariciresinol acetate(7),fomitopsin G(8),fomitopsin H(9),demalonyl fomitopsin H(10),fomlactone A(11),fomlactone B(12),fomefficinol A(13),fomefficinol B(14),laetiporins A(15),laetiporins B(16),dehydrosulphurenic acid(17),dehydroeburicoic acid(18),3-keto-dehydrosulfurenic acid(19),eburicoic acid(20).The IC50 values of compounds 7,13,20 were(4.00±1.02),(3.29±0.62),(3.22±0.94)μmol/L,respectively.CONCLUSION Compound 1 is a new compound,3,6,15,16 are isolated from this plant for the first time.Compounds 7,13,20 have strong anti-inflammatory activities.
