Chemical constituents from the buds of Aralia chinensis var.nuda and their in vitro anti-inflammatory activities
10.3969/j.issn.1001-1528.2025.01.016
- VernacularTitle:白背叶楤木芽苞化学成分及其体外抗炎活性研究
- Author:
Juan WANG
1
;
Yuan YUAN
;
Peng-cheng YIN
;
Shao-hua LI
;
Shuai CHEN
;
Hai-shan QIAN
;
Hong-fang LI
;
Hong-ping HE
;
Bao-jing LI
Author Information
1. 云南中医药大学中药学院,云南 昆明 650500
- Publication Type:Journal Article
- Keywords:
Aralia chinensis L.var.nuda Nakai;
buds;
chemical constituents;
isolation and identification;
in vitro anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2025;47(1):101-107
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the buds of Aralia chinensis L.var.nuda Nakai and their in vitro anti-inflammatory activities.METHODS The 70％ethanol extract from the buds of A.chinensis var.nuda was isolated and purified by silica gel,Sephadex LH-20,ODS and semi-preparative HPLC,then the structures of compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities in vitro were evaluated by RAW264.7 model.RESULTS Sixteen compounds were isolated and identified as 4-(2,2-dibutoxyethyl)phenol(1),trans-linalool-3,7-oxide-6-O-β-D-glucopyranoside(2),2'-O-(9Z,12Z,15Z-octadecatrienoyl)glyceryl β-D-galactopyranoside(3),quercetin-3-O-β-D-glucopyranoside(3'→ O-3''')quercetin-3-O-β-D-galactopyranoside(4),syringaresinol-4'-O-β-D-glucopyranoside(5),p-hydroxybenzaldehyde(6),7α-hydroxystigmasterol 3-O-β-D-glucopyranoside(7),trans-p-hydroxy cinnamic acid methyl ester(8),funingensin A(9),3,4-dihydroxy-acetophenone(10),N-acetyltyramine(11),3,4-di-O-caffeoyl quinic acid(12),chlorogenic acid(13),aralia cerebroside(14),caffeic acid methyl ester(15),tetradecanoic acid(16).The IC50values of compounds 8,10,12 and 13 were(22.19±1.59),(35.25±1.30),(13.38±0.72),(15.73±1.16)μmol/L,respectively.CONCLUSION Compound 1 is a new compound,2-13 are isolated from genus Aralia for the first time.Compounds 8,10,12,13 exhibit significant in vitro anti-inflammatory activities.
