Immune-related pneumonitis caused by tislelizumab
10.3760/cma.j.cn114015-20220222-00141
- VernacularTitle:替雷利珠单抗致免疫相关性肺炎
- Author:
Guangmei XIONG
1
;
Hui YANG
1
;
Shuqiao CHEN
1
;
Hao JIANG
1
Author Information
1. 陆军军医大学西南医院药学部，重庆 400038
- Publication Type:Journal Article
- Keywords:
Antineoplastic agents, immunological;
Pneumonia, interstitial;
Immune checkpoint inhibitors;
Immune-related pneumonitis;
Tislelizumab
- From:
Adverse Drug Reactions Journal
2023;25(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
A 67-year-old male patient with small cell lung cancer was given chemotherapy combined with immunotherapy (irinotecan+nedaplatin+tislelizumab), 21 days as a cycle. The patient′s cough was significantly improved without blood in sputum. After 2 cycles of treatment, chemotherapy and immunotherapy were suspended because of grade Ⅳ bone marrow suppression, and radiation therapy was changed. After the 29th radiotherapy, the patient developed paroxysmal cough and sputum with bloody, accompanied by shortness of breath and no fever. Blood gas analysis showed type Ⅰ respiratory failure. Chest computed tomography (CT) showed new pleural reticular vague shadows in both lungs, especially in the right lung. Radiotherapy was stopped and chemotherapy was restarted. The patient's cough and expectoration were improved, but the shortness of breath gradually aggravated. The interstitial pneumonia lesions involved both lungs rather than being localized, by which radiation pneumonitis were ruled out. Virus and atypical pathogen infection were excluded by etiology and imaging examination. Immune-related pneumoniatis complicated with infection caused by tislelizumab was considered. High-dose methylprednisolone combined with gamma globulin and infliximab were given to inhibit immune response, meropenem, moxifloxacin, voriconazole were given successively to prevent infection, and oxygen inhalation was given. The patient′s cough, expectoration, and shortness of breath disappeared, oxygenation index was improved, and chest CT showed that the range of interstitial changes in both lungs gradually reduced.
