Value of SIRI,LDH and AST in identifying the high-risk population of adult fulminant myocarditis
10.3969/j.issn.1673-9701.2025.02.016
- VernacularTitle:SIRI、LDH及AST用于识别成人暴发性心肌炎高危人群的价值分析
- Author:
Jingmei HE
1
;
Xiaoling ZHANG
1
;
Kun CHEN
1
Author Information
1. 浙江大学医学院附属金华医院重症医学科,浙江金华 321000
- Publication Type:Journal Article
- Keywords:
Systemic inflammatory response index;
Lactate dehydrogenase;
Aspertate aminotransferase;
Fulminant myocarditis
- From:
China Modern Doctor
2025;63(2):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of systemic inflammatory response index(SIRI),lactate dehydrogenase(LDH)and aspertate aminotransferase(AST)which is used to identify the high-risk population of adult fulminant myocarditis(FM).Methods A total of 131 adult myocarditis patients admitted to Affiliated Jinhua Hospital,Zhejiang University School of Medicine from January 2018 to December 2023 were selected as the study objects and divided into FM group(n=54)and non-FM group(n=77)according to their conditions.Differences of leukocyte count,neutrophil count,monocyte count,lymphocyte count,SIRI,C reactive protein,creatine kinase,creatine kinase,LDH,AST,and cardiac troponin I were compared.Influencing factors were analyzed by Logistic regression,and receiver operating characteristic(ROC)curve was used to analyze the predictive value.Results Upon admission,patients in non-FM group exhibited significantly lower levels of SIRI,creatine kinase,creatine kinase isoenzyme,LDH,AST,and cardiac troponin Ⅰ compared to those in FM group with statistical significance(P＜0.05).Through ROC curve analysis,it was determined that the predicted effect of LDH and AST was superior.The sensitivity of LDH and AST were found to be 75.5％and 84.9％,respectively,with corresponding specificity levels of 97.3％and 90.4％.The results of the multivariate Logistic regression analysis indicated that elevated levels of LDH＞633.00U/L,AST＞80.45U/L,and SIRI＞2.595×109/L were identified as significant risk factors associated with the development of FM in patients with myocarditis.Conclusion In the early stage of myocarditis,SIRI,LDH and AST have certain reference value for identifying the high-risk group of adult FM.
