Postoperative analgesic effects of transversus abdominis plane block versus local infiltration analgesia after laparotomy for cytoreductive surgery in patients with ovarian cancer
10.3760/cma.j.cn341190-20241119-01527
- VernacularTitle:TAPB与LIA用于卵巢癌开腹肿瘤细胞减灭术后的镇痛效果比较
- Author:
Xianqiu ZENG
1
;
Ming LI
1
;
Jintian ZHOU
1
;
Shu ZHOU
1
Author Information
1. 吉林省肿瘤医院麻醉科，长春 130000
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Cytoreduction surgical procedures;
Neuromuscular blockade;
Anesthesia, local;
Pain;
Analgesia, patient-controlled
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(10):1450-1454
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate postoperative analgesic effects of transversus abdominis plane block (TAPB) versus local infiltration analgesia (LIA) after laparotomy for cytoreductive surgery in patients with ovarian cancer. Methods:This study used a randomized controlled design. Ninety patients with ovarian cancer who underwent laparotomy for cytoreductive surgery at Jilin Cancer Hospital from June 2022 to June 2023 were prospectively included. The patients were randomly assigned to either the TAPB group or the LIA group ( n = 45 per group) using the random number table method. The TAPB group received TAPB postoperatively, while the LIA group received LIA. Postoperative pain in both groups was assessed, and the number of presses on the patient-controlled intravenous analgesia device, as well as the incidence of postoperative adverse reactions, were recorded. Results:At 6, 12, and 24 hours after surgery, the Visual Analog Scale (VAS) scores in the TAPB group were significantly lower than those in the LIA group [(2.91 ± 0.64) vs. (3.35 ± 0.82), t = -2.84, P = 0.006; (3.42 ± 0.96) vs. (4.27 ± 1.14), t = -3.83, P<0.001; (2.28 ± 0.51) vs. (2.86 ± 0.83), t = -3.99, P<0.001]. The number of presses on the patient-controlled intravenous analgesia device and the number of rescue treatments in the TAPB group were significantly lower than those in the LIA group [(10.24 ± 2.52) counts vs. (16.79 ± 4.38) counts, t = -8.70, P<0.001; (1.82 ± 0.46) counts vs. (2.68 ± 0.84) counts, t = -6.02, P<0.001]. There was no significant difference in incidence of postoperative adverse reactions including nausea, vomiting, and chills between the two groups [4.44% (2/45) vs. 6.67% (3/45), P>0.05]. Conclusions:In patients with ovarian cancer undergoing laparotomy for cytoreductive surgery, postoperative analgesia using TAPB demonstrates greater efficacy compared with LIA. TAPB more effectively alleviates postoperative pain and reduces the number of presses on the patient-controlled intravenous analgesia device, while also offering higher safety than LIA.
