Predictive value of serum Hcy combined SDF-1 for early neurological deterioration in patients with acute ischemic stroke after thrombolysis
10.3969/j.issn.1673-9701.2025.02.012
- VernacularTitle:血清Hcy、SDF-1对AIS溶栓后神经功能恶化的预测价值
- Author:
Luhan CHEN
1
;
Dandan XU
1
;
Xudong LU
1
Author Information
1. 嘉兴市第二医院神经内科,浙江嘉兴 314000
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Homocysteine;
Stromal cell-derived factor-1;
Neurological deterioration
- From:
China Modern Doctor
2025;63(2):46-49,53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum homocysteine(Hcy)and stromal cell-derived factor(SDF)-1 levels in patients with acute ischemic stroke(AIS)for early neurological deterioration(EDN)after thrombolysis.Methods From April 2023 to July 2024,134 AIS patients treated in Jiaxing Second Hospital were selected as subjects.According to the National Institutes of Health stroke scale(NIHSS)evaluation 24 hours after thrombolysis,they were divided into EDN group(n=45)and non EDN group(n=89).Enzyme-linked immunosorbent assay(ELISA)method was applied to detect serum Hcy and SDF-1 levels.Pearson method was applied to analyze correlation.Logistic regression was applied to analyze and test the influencing factors.The receiver operating characteristic curve was applied to analyze the predictive value of indicators for EDN.Results The serum Hcy,SDF-1 levels,admission to puncture time,and baseline NIHSS score in EDN group were higher than those in non EDN group(P＜0.05).The levels of serum Hcy and SDF-1 in AIS patients were positively correlated with admission to puncture time and baseline NIHSS score(P＜0.05).Hcy and SDF-1 were independent influencing factors for EDN in AIS patients after thrombolysis(P＜0.05).The area under the curve of Hcy and SDF-1 combination for predicting EDN was 0.963,with sensitivities of 88.98％,and specificities of 94.43％,respectively.The prediction critical values of Hcy and SDF-1 were 25.31μmol/L and 159.10μg/L.Conclusion Serum Hcy and SDF-1 levels increase in AIS patients with EDN after thrombolysis.The combination of the two has important clinical predictive value for EDN.
