Real-time functional MRI neurofeedback for modulating brain activity changes in obese adults
10.13929/j.issn.1003-3289.2025.01.010
- VernacularTitle:实时功能MRI神经反馈技术干预后成年肥胖者脑活动改变
- Author:
Qi QIAO
1
;
Jing ZHOU
;
Junya HE
;
Xin LI
;
Yang ZHOU
;
Zhonglin LI
;
Zhi ZOU
;
Xiaoling WU
;
Hao LI
;
Yongli LI
Author Information
1. 郑州大学人民医院/河南省人民医院医学影像科,河南郑州 450003
- Publication Type:Journal Article
- Keywords:
obesity;
brain;
magnetic resonance imaging;
functional neuroimaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe value of real-time functional MRI neurofeedback(rtfMRI-NF)for modulating brain activity changes in obese adults.Methods Twenty-two obese adults were prospectively recruited,3-week rtfMRI-NF training intervention was conducted.Barratt impulsivityness scale version 11(BIS-11),three-factor eating questionnaire(TFEQ)and food rating scales were scored before and after intervention,and whole-brain resting state fMRI(rs-fMRI)data were obtained.Clinical scale scores,rs-fMRI regional homogeneity(ReHo)values and amplitude of low frequency fluctuation(ALFF)values were compared before and after intervention.Then brain regions with differences of ReHo and ALFF values before and after intervention were explored,and correlations of values of rs-fMRI data differences and clinical scale score differences were analyzed.Results BIS-11 score,TFEQ emotional eating(TFEQ-EE)score and food rating scales scores decreased,while TFEQ cognitive restraint(TFEQ-CR)scores increased in obese adults after intervention(all P＜0.05).ReHo values in right inferior frontal gyrus,right anterior cingulate and left precuneus increased,while of left middle temporal gyrus decreased(all corrected P＜0.05).ALFF values of left precuneus increased,whereas of left middle occipital gyrus,right superior occipital gyrus,left calcarine fissure and surrounding cortex and left supramarginal and angular gyrus decreased(all corrected P＜0.05).ReHo difference in right anterior cingulate was negatively correlated with BIS-11 scores difference(r=-0.601,P＜0.05),and ALFF difference in left precuneus was negatively correlated with TFEQ-EE difference(r=-0.478,P＜0.05).Conclusion rtfMRI-NF intervention could correct disorder of cerebral functional areas in obese adults and change high-calorie food preference and poor dietary habits.
