Hand-foot syndrome caused by doxorubicin hydrochloride liposome injection
10.3760/cma.j.cn114015-20211222-01291
- VernacularTitle:盐酸多柔比星脂质体注射液致手足综合征
- Author:
Zhiqi ZHANG
1
;
Jie GAO
1
Author Information
1. 苏州大学附属第一医院药学部，苏州 215006
- Publication Type:Journal Article
- Keywords:
Hand-foot syndrome;
Doxorubicin;
Liposomes
- From:
Adverse Drug Reactions Journal
2022;24(8):439-441
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old female patient with breast cancer received cyclophosphamide and doxorubicin hydrochloride liposome injection chemotherapy twice after modified radical mastectomy. The patient was pretreated with dexamethasone injection 5 mg before chemotherapy. After each chemotherapy, mucosal ulcer of different degrees occurred, and both hands and feet were red and swollen, which showed an aggravating trend, but were all improved after a few days. After the 3rd chemotherapy, the patient′s hands and feet were red and swollen, accompanied by blisters and exudation, her body temperature rose up to 40.0 ℃, with large area of erythema on his back, axillary erythema with erosion exudation, and oral mucosal ulcer. It was considered that the patient was likely to have hand-foot syndrome. Methylprednisolone, cefoxitin, omeprazole, and other drugs, external skin care measures such as wet compress of the affected area with furacilin solution and keeping the skin moist were given. After 15 days of treatments, the patient′s hands and feet symptoms were improved. Then doxorubicin hydrochloride liposomes injection were stopped and replaced by docetaxel, and hand and foot symptoms in the patient did not recur.
