Edaravone injection-associated neutropenia
10.3760/cma.j.cn114015-20220110-00012
- VernacularTitle:依达拉奉注射液相关中性粒细胞减少
- Author:
Bihong CHEN
1
;
Yuqin SHEN
;
Huaiqiang HU
Author Information
1. 潍坊医学院临床医学院，潍坊 261053
- Publication Type:Journal Article
- Keywords:
Free radical scavengers;
Leukopenia;
Neutropenia;
Edaravone
- From:
Adverse Drug Reactions Journal
2022;24(8):435-436
- CountryChina
- Language:Chinese
-
Abstract:
A 54-year-old male patient with amyotrophic lateral sclerosis received mecobalamin, idebenone, coenzyme Q10, etc. After 1 week of treatment, edaravone injection, citicoline sodium capsules, and vitamin E capsules were added because the patient had no significant improvement in upper limb weakness, chest tightness, and suffocation. On day 10 of edaravone injection treatment, the patient developed increased sweat on his head and neck. Laboratory tests showed white blood cell count 1.7×10 9/L, neutrophil percentage 0.25, and neutrophil count 0.4×10 9/L. Neutropenia was considered, which might be related to edaravone. Edaravone injection was stopped, other treatments were continued, and a subcutaneous injection of granulocyte stimulating factor injection 150 μg was given once. Two days later, the white blood cell count was 9.6×10 9/L, neutrophil was percentage 0.72, and neutrophil count was 6.9×10 9/L.
