Acute kidney injury induced by canagliflozin
10.3760/cma.j.cn114015-20211123-01181
- VernacularTitle:卡格列净致急性肾损伤
- Author:
Hongmei ZHANG
1
;
Qiushi GUO
1
;
Xu TIAN
1
;
Lirui SUN
1
Author Information
1. 吉林大学第一医院二部药学部，长春 130031
- Publication Type:Journal Article
- Keywords:
Canagliflozin;
Sodium-glucose transporter 2 inhibitors;
Acute kidney injury
- From:
Adverse Drug Reactions Journal
2022;24(7):376-377
- CountryChina
- Language:Chinese
-
Abstract:
A 45-year-old male patient was treated with canagliflozin 100 mg once daily orally for type 2 diabetes mellitus due to poor blood sugar control. On the 4th day of medication, the patient developed slight abdominal distension and fatigue; on the 5th day, the patient felt nausea and general fatigue, and the color of urine became dark brown. The laboratory tests showed serum creatinine (Scr) 136 μmol/L, blood urea nitrogen (BUN) 9.7 mmol/L, urine protein (+), and urinary occult blood (++). Acute kidney injury induced by canagliflozin was considered. Canagliflozin was stopped, and acarbose 50 mg (before meal), 2 Haikun Shenxi capsules (海昆肾喜胶囊), and 3 Jinshuibao capsules (金水宝胶囊) orally thrice daily were given. After 2 days of drug withdrawal, the symptoms of nausea and fatigue disappeared, and the color of urine was normal. After 5 days of drug withdrawal, laboratory tests showed fasting blood glucose 5.6 mmol/L, Scr 112 μmol/L, BUN 8.5 mmol/L, urine protein (-), and urine occult blood (-). After 19 days of drug withdrawal, the patient′s renal function indexes were all within the normal range, and no discomfort symptoms recurred.
