The role and mechanisms of lncRNA and miRNA in metabolic repro-gramming regulation in hepatocellular carcinoma
10.12092/j.issn.1009-2501.2025.09.013
- VernacularTitle:以lncRNA和miRNA为主在肝癌代谢重编程调控中的作用和机制
- Author:
Yan JIANG
1
;
Cangsang SONG
;
Guohui WANG
;
Panpan MAO
;
Xingde LI
Author Information
1. 昆明医科大学,昆明 650500,云南;昆明市第一人民医院药学部,昆明 650000,云南
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
non-cod-ing RNAs;
metabolic reprogramming;
glucose me-tabolism;
lipid metabolism;
amino acid metabolism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(9):1260-1271
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC)is a cancer with extremely high mortality and incidence rates.In recent years,with the development of multidisciplinary approaches,key characteristics of cancer have gradually been revealed.Studies have shown that dysregulated energy metabolism and metabolic reprogramming in tumor cells form the basis for tumor cell growth and are critical factors in shaping the tumor microenvironment,immune evasion,and drug resistance.Non-coding RNAs(ncRNAs),as important regulatory factors,play a crucial role in the metabolic reprogramming of HCC.This article focuses on summarizing the mech-anisms by which ncRNAs regulate metabolic repro-gramming in HCC and explores their applications in clinical diagnosis,treatment,and prognostic assess-ment,aiming to provide new perspectives for effec-tive HCC treatment and the development of novel drug targets.
