Correlation between brain abnormal glucose metabolism and striatal dopaminergic neuron damage in early-stage Parkinson disease patients
10.13929/j.issn.1003-3289.2025.01.008
- VernacularTitle:早期帕金森病患者脑葡萄糖代谢异常与纹状体多巴胺能神经元受损的相关性
- Author:
Shaung LI
1
;
Shaozhen YAN
;
Weizhao LU
;
Tianbin SONG
;
Chang YANG
;
Chun ZHANG
;
Jie LU
Author Information
1. 湖北医药学院附属襄阳市第一人民医院核医学科,湖北襄阳 441000;首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京市重点实验室,北京 100053
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
brain;
positron-emission tomography;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation between brain abnormal glucose metabolism and striatal dopaminergic neuron damage in early-stage Parkinson disease(PD)patients.Methods Thirty-two early-stage PD patients(PD group)and 18 healthy individuals(control group)were prospectively enrolled,and 18F-FDG and 18F-9-fluoropropyl-(+)-dihydrotetrabenazine(18 F-FP-DTBZ)PET/MR brain imaging were performed.The degrees of uptake were compared between groups,and the correlation between brain abnormal glucose metabolism and striatal dopaminergic neuron damage was analyzed.Results Compared with control group,18F-FDG PET showed that in PD group glucose metabolism decreased in bilateral frontal and parietal lobes but increased in bilateral putamen,pons and bilateral cerebellum(all P＜0.05),while18 F-FP-DTBZ PET showed that in PD group glucose metabolism decreased in bilateral caudate nucleus,anterior putamen and posterior putamen(all P＜0.05).In PD group,the mean standard uptake value(SUVmean)of putamen was positively correlated with the standard uptake value ratio(SUVR)of contralateral caudate nucleus(r=0.305,P=0.014),while SUVmean of frontal cortex was positively correlated with SUVR of contralateral and symptomatic caudate nucleus(r=0.352,0.324,both P＜0.05)as well as anterior putamen(r=0.300,0.314,both P＜0.05),SUVmean of the partial cortex in parietal lobe was positively correlated with SUVR of contralateral and symptomatic caudate nucleus and contralateral anterior putamen(r=0.329,0.303,0.330,all P＜0.05).Conclusion Brain abnormal glucose metabolism had certain correlation with striatal dopaminergic neuron damage in early-stage PD patients.
