Risk factors for postoperative recurrence in solitary fibrous tumor of the central nervous system
10.3969/j.issn.1002-1671.2025.10.005
- VernacularTitle:中枢神经系统孤立性纤维肿瘤术后复发的危险因素分析
- Author:
Min GUO
1
;
Anqi CHEN
1
;
Huizhen LU
1
;
Yongfei HAO
1
;
Dandan LI
1
;
Yingjuan CHANG
1
;
Xing TANG
1
Author Information
1. 空军军医大学西京医院放射科,陕西 西安 710032
- Publication Type:Journal Article
- Keywords:
central nervous system;
solitary fibrous tumor;
magnetic resonance imaging;
recurrence;
pathological grading;
Ki-67
- From:
Journal of Practical Radiology
2025;41(10):1614-1618
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the imaging data and pathological factors affecting the postoperative recurrence of solitary fibrous tumor(SFT)of the central nervous system.Methods A retrospective analysis was conducted on the data of 40 patients with SFT confirmed by pathology.All patients were divided into recurrence group(n=12)and non-recurrence group(n=28)based on the follow-up results.Univariate analysis and Cox proportional hazards model were used to screen the risk factors of recurrence,and the Kaplan-Meier method was used to compare the recurrence-free survival(RFS)among different groups.Results Univariate analysis showed that the Ki-67 index in the recurrence group was significantly higher than that in the non-recurrence group(median 38.5%vs 10.0%,P<0.001),and the proportion of WHO grade 3 was higher than that in the non-recurrence group(66.67%vs 7.14%,P<0.001).MRI features were significantly associated with recurrence,including the maximum diameter of the tumor[(6.63±1.10)cm vs(4.16±1.64)cm,P<0.001],peritumoral edema(91.67%vs 28.57%,P<0.001),and midline structure shift(83.33%vs 17.86%,P<0.001).Multivariate analysis suggested that the risk of recurrence increased by 122%for each 1 cm increase in the maximum diameter of the tumor[hazard ratio(HR)=2.22,95%confidence interval(CI)1.33-3.72],and by 27%for each 1%increase in the Ki-67 index(HR=1.27,95%CI 1.02-1.61),respectively.Conclusion MRI features such as maximum diameter of the tumor,significant peritumoral edema,and midline structure shift should be alert to high recurrence risk,and with pathological grading and Ki-67 index,it can provide significant basis for prognosis evaluation.
