Study on the prediction of Ki-67 expression level in nasopharyngeal carcinoma by multi-parameter MRI

VernacularTitle:多参数MRI预测鼻咽癌Ki-67表达水平的研究
Author: Zhiying MO ¹ ; Wenjuan ZHOU ; Huaxin LI ; Bingwei LIU ; Jinyuan LIAO
Author Information

1. 梧州市人民医院放射科,广西梧州 543000
Publication Type:Journal Article
Keywords: magnetic resonance imaging; multi-parameter; nasopharyngeal carcinoma; Ki-67
From: Journal of Practical Radiology 2025;41(10):1629-1632,1638
CountryChina
Language:Chinese
Abstract: Objective To explore the value of multi-parameter MRI in predicting the Ki-67 expression level in nasopharyngeal carcinoma(NPC).Methods The clinical and MRI data of 63 patients with pathologically confirmed NPC were prospectively collected.All patients underwent routine plain and enhanced nasopharyngeal MRI,diffusion weighted imaging(DWI),and arterial spin labeling(ASL)scans before treatment.Multivariate logistic regression analysis was used to identify the independent risk factors for the Ki-67 expression level.Results The degree of enhancement,the maximum blood flow(BFmax),and the minimum apparent diffusion coefficient(ADCmin)were independent risk factors for the Ki-67 expression level in NPC patients.The area under the curve(AUC)of the prediction model established based on these three factors was 0.920,with a sensitivity of 0.792 and a specificity of 0.897,respectively.Conclusion Multi-parameter MRI based on conventional enhancement,ASL,and DWI can effectively predict the Ki-67 expression level in NPC patients.