Advances in targeting neuroinflammatory for futile recanalization after endovascular treatment of ischemic stroke
10.3969/j.issn.1002-0152.2025.08.008
- VernacularTitle:缺血性脑卒中血管内治疗后无效再通的靶向神经炎症干预研究进展
- Author:
Xiaoying ZENG
1
;
Xuxuan GAO
1
;
Jia YIN
1
Author Information
1. 南方医科大学南方医院神经内科(广州 510515)
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Neuroinflammation;
Futile recanalization;
Endovascular therapy;
No-reflow phe?nomenon;
Cerebral ischemia-reperfusion injury;
Brain-gut axis
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(8):490-495
- CountryChina
- Language:Chinese
-
Abstract:
With the advancement of endovascular therapy(EVT)techniques,the recanalization rate for patients with ischemic stroke(IS)has exceeded 80%.However,more than 50%of patients fail to achieve favorable neurological outcomes following recanalization,a phenomenon termed"futile recanalization"(FR).Neuroinflammation plays a pivotal role in the pathological progression of IS and is closely associated with the development of FR.This systematic review synthesizes the pivotal role of neuroinflammation in FR,encompassing three core pathological mechanisms:the no-reflow phenomenon,cerebral ischemia-reperfusion injury,and the gut-brain axis.The identification of various inflammation-related biomarkers shows promise for early detection of high-risk FR patients.Therapeutic agents including TLR4 antagonists(e.g.ApTOLL),neuroprotective compounds,and traditional Chinese medicine formulations demonstrate treatment potential through modulation of neuroinflammatory pathways.Targeted interventions against neuroinflammation may emerge as a strategic approach to improve clinical outcomes in IS patients.
