A case report of relapsed and refractory multiple myeloma with multifocal extramedullary infiltration and pulmonary adenocarcinoma
10.3969/j.issn.1674-8115.2025.01.015
- VernacularTitle:复发难治性多发性骨髓瘤伴多病灶髓外浸润合并肺腺癌1例报道
- Author:
Fang DU
1
;
Lingyun ZHOU
1
;
Jiao CHEN
1
;
Danbo LIU
1
;
Hongxian XIANG
1
;
Haifei CHEN
1
Author Information
1. 广东省深圳市罗湖区人民医院血液内科,深圳 518005
- Publication Type:Journal Article
- Keywords:
relapsed and refractory multiple myeloma;
extramedullary infiltration;
pulmonary adenocarcinoma;
synchronous coexistence;
diagnosis and treatment
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2025;45(1):122-128
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)remains an incurable disease,with most patients experiencing multiple relapses before ultimately progressing to refractory stage.Extramedullary infiltration is a common manifestation of relapse.However,distinguishing synchronous multifocal extramedullary infiltration from secondary malignancies poses significant diagnostic challenges.This study presents a case of relapsed refractory MM with multifocal extramedullary infiltration,diagnosed as coexistence of multiple myeloma extramedullary infiltration and pulmonary adenocarcinoma through multidisciplinary team(MDT)collaboration.Such coexistence is exceedingly rare in clinical practice and introduces substantial complexity in diagnosis and treatment planning.Through a comprehensive case report and literature review,this paper explores the diagnostic and therapeutic approaches to managing multifocal extramedullary infiltration coexisting with secondary malignancies in MM,highlighting the pivotal role of MDT in achieving precise diagnosis and optimizing patient outcomes.
