Influencing Factor Analysis and Prediction Model Construction of Immune-Related Thyroid Dysfunction Caused by Sintilimab Treatment in Solid Tumors
10.3870/j.issn.1004-0781.2025.10.005
- VernacularTitle:信迪利单抗治疗实体瘤致免疫相关性甲状腺功能异常的影响因素及预测模型构建
- Author:
Yanjun CUI
1
;
Tian MA
;
Yi LIU
;
Libo ZHAO
;
Xinyi DU
;
Ling JIAO
;
Aijun CHAI
;
Rongrong FAN
;
Yanguo LIU
;
Lin HUANG
;
Xiaohong ZHANG
Author Information
1. 石家庄市人民医院/北京大学人民医院石家庄医院药学部,石家庄 050000
- Publication Type:Journal Article
- Keywords:
Sintilimab;
Thyroid dysfunction;
Programmed cell death-1 inhibitors;
Immune-related adverse events
- From:
Herald of Medicine
2025;44(10):1556-1561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing factors of immune-associated thyroid dysfunction caused by sintilimab treatment in solid tumors and construct a prediction model.Methods Medical records of patients diagnosed with solid tumors and treated with sintilimab at Peking University People's Hospital(Xizhimen Campus,Tongzhou Campus,Shijiazhuang Campus)from January 2023 to September 2024 were collected to explore the influencing factors that caused immune-related thyroid dysfunction using univariate and multifactorial binary logistic regression analyses and to establish a prediction model.The predictive effect of the model was assessed using the receiver operating characteristic(ROC)curve.Results A total of 120 patients were included,and 33 presented with immune-related thyroid dysfunction.Multifactorial logistic regression analysis revealed that thyroid-stimulating hormone(TSH)[OR=2.470,95%CI=(1.279,4.771)]and treatment cycles[OR=1.298,95%CI=(1.117,1.509)]were independent risk factors for the occurrence of immune-associated thyroid dysfunction,and the difference was statistically significant(P＜0.05).The area under the ROC curve was(0.897±0.043)[95%CI=(0.813,0.981)],the Yoden index was 0.703,and the model prediction accuracy was 86.5%.Conclusion The risk of immune-related thyroid dysfunction caused by sintilimab is high,and TSH and treatment cycle are the influencing factors,and the constructed model has certain predictive value and is of reference significance.
