Neuropsychiatric Abnormalities Following Metoclopramide:A Case Report in Hyperemesis Gravidarum
10.3870/j.issn.1004-0781.2025.10.028
- VernacularTitle:甲氧氯普胺注射液治疗妊娠剧吐致精神异常1例
- Author:
Danna GAN
1
;
Yuan LI
;
Shaolian SONG
;
Canmao WANG
;
Chunyan TANG
;
Hongliang MEI
Author Information
1. 南方医科大学深圳医院药剂科,深圳 518000
- Publication Type:Journal Article
- Keywords:
Metoclopramide;
Hyperemesis gravidarum;
Mania;
Drowsiness;
Neuropsychiatric abnormalities
- From:
Herald of Medicine
2025;44(10):1684-1687
- CountryChina
- Language:Chinese
-
Abstract:
Hyperemesis gravidarum(HG)refers to persistent and severe nausea and vomiting during early pregnancy.Severe HG may lead to maternal dehydration,electrolyte imbalances,malnutrition,and even hypotension and arrhythmias,potentially affecting fetal growth and development.Due to the unique physiological state of pregnancy,treatment options for HG are limited.Metoclopramide,has become a commonly used drug in treating HG due to its prove efficacy and safety.Previous studies have primarily focused on the extrapyramidal side effects of metoclopramide,but research on its psychiatric adverse effects,such as mania and somnolence,remains limited,particularly in pregnant patients.This paper reports a case of psychiatric abnormalities in an HG patient following metoclopramide administration.By analyzing the patient's condition,medication use,and adverse reactions,this study explores the potential mechanisms underlying metoclopramide-induced psychiatric abnormalities and provides clinical recommendations for preventing and managing such psychiatric adverse effects during pregnancy.These findings offer valuable guidance for healthcare professionals regarding the appropriate use of this medication.
