Research Progress and Application Prospects of Sotatercept in Pulmonary Arterial Hypertension
10.3870/j.issn.1004-0781.2025.10.023
- VernacularTitle:索特西普在动脉型肺动脉高压中的研究进展及应用前景
- Author:
Yuxi XIA
1
;
Yaqian BAI
1
;
Haokang SU
1
;
Tiantian ZHU
1
Author Information
1. 河南医药大学药学院,新乡 453003
- Publication Type:Journal Article
- Keywords:
Sotatercept;
Pulmonary arterial hypertension;
Pulmonary vascular resistance
- From:
Herald of Medicine
2025;44(10):1661-1666
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary arterial hypertension(PAH)is a serious and fatal cardiovascular disease that significantly affects patients'quality of life and survival.Current treatments offer some relief but have limited effectiveness and notable side effects.Sotatercept,as a novel drug,modulates the transforming growth factor-β(TGF-β)signaling pathway and shows promising therapeutic effects in PAH.By summarizing the pharmacological mechanisms and clinical research progress of sotatercept in PAH,assessing its application prospects,and analyzing future research directions in the light of current clinical research results,we provide an important perspective for understanding the clinical application of this drug in China,with a view to promoting its promotion and application in China.
