Research Progress of the Dual Role of Autophagy in Herb-Induced Liver Injury and its Prevention and Treatment Strategies
- VernacularTitle:细胞自噬在中药源性肝损伤中的双重作用及防治策略研究进展
- Author:
Tingping ZHANG
1
;
Mengyu LI
;
Chunyu GU
;
Jingqi HU
;
Jiao KONG
;
Chuanxin LIU
Author Information
- Publication Type:Journal Article
- Keywords: Autophagy; Herb-induced liver injury; Signal pathway; Control strategy Action mechanism
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(9):2219-2228
- CountryChina
- Language:Chinese
- Abstract: Objective This article systematically reviews the interaction between autophagy and herb-induced liver injury,and it elucidates the mechanism of liver injury.Also,it summarizes the control strategies of herb-induced liver injury.Methods Based on the retrieval of CNKI,Wanfang,PubMed and Web-of-Science databases,the literature on autophagy and herb-induced liver injury in the past decade was reviewed to clarify the relationship between autophagy and disease occurrence.Then we summarize common drugs and the mechanism of herb-induced liver injury caused by autophagy.The control strategies of herb-induced liver injury were summarized,too.Results Autophagy plays a dual role in the herb-induced liver injury.Autophagy pathway and autophagy-related molecules can be changed in the case of excessive activation or excessive inhibition to cause herb-induced liver injury.Conclusion The regulation of autophagy pathway is expected to be a new method for the prevention and treatment of herb-induced liver injury.Targeted control strategies are important measures to realize the safety risk monitoring of Chinese herbal medicine.
