Role of tumor-associated macrophages in osteosarcoma and the implications for targeted therapy
10.12354/j.issn.1000-8179.2024.20241424
- VernacularTitle:肿瘤相关巨噬细胞在骨肉瘤中的作用及其靶向治疗的意义
- Author:
Yue ZELIN
1
;
Wang TIANHUA
;
Qu XINTIAN
;
Gong HAOQUAN
;
Li NIANHU
Author Information
1. 山东中医药大学第一临床医学院(济南市 250014)
- Publication Type:Journal Article
- Keywords:
osteosarcoma(OS);
tumor-associated macrophages;
tumor microenviroment(TME);
targeted therapy
- From:
Chinese Journal of Clinical Oncology
2024;51(24):1285-1290
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma(OS)is a common primary malignant bone tumor occurring predominantly in children and adolescents.The main treatments for OS are surgical resection and chemotherapy.Although overall survival rates have improved,progress has stalled in recent years,particularly in cases of recurrence and metastasis.The tumor microenvironment(TME)is closely related to tumor development,and macrophages are among the most abundant immune cells within the tumor environment.As a new target for tumor immunotherapy,mac-rophages have gained increasing attention due to their significant role in tumor progression.In this review,we explore the role of macro-phages in the OS microenvironment and discuss their clinical significance and involvement in the occurrence and development of OS.Fur-thermore,we summarize the therapeutic strategies targeting macrophages for OS treatment.
