Early identification of high-risk children who develop systemic adverse reactions related to dust mite al-lergy subcutaneous immunotherapy
10.3969/j.issn.1006-5725.2025.19.016
- VernacularTitle:尘螨过敏皮下免疫治疗相关性全身不良反应高危儿的早期识别
- Author:
Muying HUANG
1
;
Chu LIU
;
Jiaman LIU
;
Zhicong WANG
Author Information
1. 普宁市中医医院儿科(广东 揭阳 515300)
- Publication Type:Journal Article
- Keywords:
dermatophagoides pteronyssinus;
subcutaneous immunotherapy;
dust mite-specific IgE;
omalizumab
- From:
The Journal of Practical Medicine
2025;41(19):3065-3071
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify children with high-risk systemic adverse reactions(SARs)associated with dust mite subcutaneous immunotherapy prior to immunotherapy.Methods An analysis was conducted on the high-risk factors in patients who experienced SARs prior to initial immunotherapy.A total of 40 pediatric patients with dust mite allergic rhinitis who underwent treatment with Dermatophagoides pteronyssinus(Dp)extracts at our hospital's pediatric department from April 2021 to January 2025 and developed SARs were selected as the observa-tion group,while 54 patients who did not experience SARs served as the control group.Differences in gender,age,disease duration,eosinophil count,polysensitization,multisystem involvement,total IgE(tIgE),and dust mite-specific IgE(sIgE)were evaluated.Results Significant differences were observed between the observation and control groups in polysensitization,multisystem involvement,and tIgE levels.The polysensitization rates were 70%vs.48.1%(P=0.034),multisystem involvement 55%vs.22.2%(P=0.001),and high tIgE levels(tIgE≥327.8 IU/mL)82.5%vs.62.1%(P=0.025).Multivariate logistic regression identified multisystem involvement[OR(95%CI)=4.278(1.749～10.461)]as an independent risk factor for SARs during allergen immunotherapy(AIT).Conclusion Patients with dust mite allergic rhinitis accompanied by multi-system damage exhibit poorer conventional prevention efficacy against SARs when undergoing AIT.They remain highly susceptible to SARs occur-rence,necessitating more robust preventive measures against SARs to enhance the safety of AIT.
