A randomized controlled trial on the efficacy of compound polyethylene glycol electrolyte powder com-bined with linaclotide for bowel preparation in elderly constipated patients before colonoscopy
10.3969/j.issn.1006-5725.2025.19.002
- VernacularTitle:复方聚乙二醇电解质散联合利那洛肽改善老年便秘患者结肠镜前肠道准备效果的随机对照研究
- Author:
Jianjun ZHANG
1
;
Haipeng WANG
;
Guangfeng DONG
;
Ming CHEN
;
Jinqi LIU
;
Hao ZHANG
;
Mingjuan SUN
;
Meng LU
;
Huizhuan ZHAI
;
Xingguang HUANG
;
Zengjun LI
;
Dongyang WANG
Author Information
1. 山东第一医科大学附属肿瘤医院肿瘤内科(山东 济南 250117)
- Publication Type:Journal Article
- Keywords:
colonoscopy;
intestinal preparation;
polyethylene glycol;
linalotide;
elderly patients;
constipation
- From:
The Journal of Practical Medicine
2025;41(19):2967-2971
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of polyethylene glycol electrolyte powder(PEG)combined with linaclotide(Lin)for bowel preparation in elderly constipated patients before colonoscopy.Methods In this prospective,randomized controlled trial,90 elderly patients with constipation undergoing colonoscopy were recruited at our hospital from June 2022 to December 2023.Participants were randomly assigned to three groups(n=30 each):PEG-3L alone,PEG-3L+Lin,and PEG-2L+Lin.Primary outcome was Boston Bowel Preparation Scale(BBPS)score and secondary outcomes included adverse event rates,colonoscopy completion rate,withdrawal time,and polyp detection rate.Statistical analysis was performed using independent t-tests and chi-square tests.Results The PEG-3L+Lin group achieved significantly higher BBPS scores than both PEG-3L alone and PEG-2L+Lin groups did(both P<0.001).The PEG-2L+Lin group also outperformed the PEG-3L alone group in cleansing efficacy(90.0%vs.76.7%,P=0.008).The PEG-2L+Lin group demonstrated the best tolerability and lowest adverse event rate,the PEG-3L group had the longest withdrawal time(P<0.05),but the three groups showed no significant difference in polyp detection rates.Conclusion PEG combined with linaclotide significantly improves bowel cleansing in elderly constipated patients.PEG-2L+Lin regimen provides optimal balance between efficacy,safety,and tolerability,making it a preferable choice for this population.
