Research progress in metabolomics of fentanyl analogs
10.13618/j.issn.1001-5728.2025.04.017
- VernacularTitle:芬太尼类物质的代谢组学研究进展
- Author:
Wanting XIE
1
;
Baohua SHEN
;
Yan SHI
Author Information
1. 司法鉴定科学研究院,上海市法医学重点实验室,上海市司法鉴定专业技术服务平台,司法部司法鉴定重点实验室,上海 200063;中国药科大学药学院,江苏南京 210009
- Publication Type:Journal Article
- Keywords:
Fentanyl;
Metabolomics;
New psychoactive substances;
Opioid receptor
- From:
Chinese Journal of Forensic Medicine
2025;40(4):480-486
- CountryChina
- Language:Chinese
-
Abstract:
The widespread abuse and high fatality rate of fentanyl and its analogs have posed a severe threat to global public health and safety.Metabolomics has emerged as a research hotspot in forensic science,as it enables the construction of in vivo models of drug toxicity mechanisms at the molecular level without direct drug detection,thereby elucidating metabolic pathways and evaluating toxic effects.Based on recent studies,this paper reviews commonly used strategies for metabolomics research and summarizes advances regarding endogenous biomarkers,metabolites,and toxicity mechanisms of fentanyl analogs,providing a reference for the application of metabolomics in the detection and control of these substances.
