Automatic synthesis of 18 F-MK-6240 with AllinOne synthesis module and preliminary application in Alzheimer disease
10.13929/j.issn.1003-3289.2024.12.022
- VernacularTitle:基于AllinOne合成模块自动化合成18F-MK-6240并初步用于阿尔茨海默病
- Author:
Zhenghai HUANG
1
;
Chao REN
;
Meiqi WU
;
Xianzhong ZHANG
;
Li HUO
Author Information
1. 中国医学科学院北京协和医学院北京协和医院临床医学研究所,北京 100730;中国医学科学院北京协和医学院北京协和医院核医学科,北京 100730
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
tau proteins;
positron-emission tomography and computed tomography;
18F-MK-6240
- From:
Chinese Journal of Medical Imaging Technology
2024;40(12):1909-1913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the preliminary application value of 18 F-MK-6240 automatically synthesized with AllinOne synthesis module in Alzheimer disease(AD).Methods Based on AllinOne synthesis module,18 F-labeled intermediate 18F-MK-6240-Boc was formed with 18F-MK-6240 precursor through nucleophilic reaction with 18 F-.After hydrolyzed by acid,separated by high performance liquid chromatography and purified by solid-phase extraction,18F-MK-6240 was obtained,and quality control was performed.18F-MK-6240 PET/CT scanning was performed in 1 AD patient and 1 non-AD patient with cognitive impairment who were prospectively enrolled,and the preliminary application value of the product was observed.Results 18 F-MK-6240 was successfully automatically synthesized based on AllinOne synthesis module,the synthesis time was 80 min,no-corrected synthesis efficiency was 20.74％±2.31％,radiochemical purity was greater than 95％,and sterility test,bacterial endotoxins test,abnormal toxicity test and solvent residual test all met national standards.18F-MK-6240 PET/CT showed tau protein deposition of bilateral frontal,parietal,temporal and insular lobes in AD patients,while no tau protein deposition was observed in non-AD patients with cognitive impairment.Conclusion 18F-MK-6240 could be automatically synthesized based on AllinOne synthesis module,with qualified product quality and clinical application value in AD.
