Association of miR-223,platelet parameters and coagulation indicators with stable angina pectoris and their predictive value for it
10.3969/j.issn.1008-0074.2024.06.12
- VernacularTitle:miR-223、血小板参数及凝血指标与稳定型心绞痛的相关性及对其的预测价值
- Author:
Zhi XING
1
;
Zhuo CHEN
;
Ying GAO
;
PALIDA·ABULAITI
;
Hui LI
;
SHAJIDAN·ABUDUREYIMU
Author Information
1. 新疆医科大学第一附属医院综合内三科,新疆乌鲁木齐 830011
- Publication Type:Journal Article
- Keywords:
Angina,Stable;
MicroRNAs;
Fibrinogen
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(6):710-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to analyze association of serum microRNA(miR)-223,platelet parameters and co-agulation indicators with stable angina pectoris(SAP)and their predictive value for it.Methods:A total of 150 SAP pa-tients admitted in First Affiliated Hospital of Xinjiang Medical University between January 2019 and January 2021 were en-rolled as SAP group,another 150 subjects without coronary heart disease were selected as control group.MiR-223,plate-let parameters and coagulation indicator levels were compared between two groups.Spearman method was used to analyze the association of above-mentioned indexes with severity of coronary artery disease(Gensini score),and ROC curve was used to analyze the diagnostic value of miR-223 and fibrinogen(Fg)for SAP.Results:Patients in SAP group had signifi-cant higher miR-223,Fg,Fg degradation products,D dimer and platelet distribution width,and significant lower platelet count compared to control group(P＜0.05 or＜0.01).Spearman correlation analysis indicated that Fg and miR-223 were positively correlated with severity of coronary artery disease(r=0.228,0.269,P=0.013,0.001).ROC curve a-nalysis showed that miR-223[area under the curve(AUC)=0.851]and Fg(AUC=0.692)had good predive value for SAP.Conclusion:Serum miR-223 and fibrinogen are associated with severity of coronary artery disease.They could be used as reference indexes for diagnosis and assessment of stable angina pectoris.
