Research progress in intervention of traditional Chinese medicine in MAPK signaling pathway for prevention and treatment of Alzheimer disease
10.3969/j.issn.1000-4718.2025.09.018
- VernacularTitle:中医药干预MAPK信号通路防治阿尔茨海默病的研究进展
- Author:
Huanning JIANG
1
;
Yanyan ZHOU
1
;
Qi WANG
1
;
Quan LI
1
Author Information
1. 黑龙江中医药大学基础医学院,黑龙江 哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
traditional Chinese medicine;
mitogen-activated protein kinase
- From:
Chinese Journal of Pathophysiology
2025;41(9):1823-1831
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease(AD)is a progressive neurodegenerative disorder characterized by cognitive dysfunction and declining learning and memory abilities,significantly impacting daily lives and behavioral capacities of the patients.The mitogen-activated protein kinase(MAPK)signaling pathway,primarily composed of extracellular signal-regulated kinase,p38 MAPK,and c-Jun N-terminal kinase.Mounting evidence suggests that the MAPK signaling path-way is intimately linked to the pathogenesis of AD,providing crucial insights into the disease's progression.In recent years,traditional Chinese medicine(TCM)has demonstrated promising potential in treating AD,with its advantages of personalized therapy and multi-target regulation garnering increasing research attention.This study aims to review the ex-perimental research landscape of TCM interventions targeting the MAPK signaling pathway for the prevention and treat-ment of AD over the past five years.The findings reveal that effective compounds and herbal formulas in TCM,such as isorhamnetin,nobiletin,parthenolide,Glehnia littoralis,Ishige okamurae,shikonin,artemisinin,kaempferol,myrice-tin,and Tripterygium glycosides,can alleviate AD symptoms by modulating the MAPK signaling pathway.These interven-tions mitigate Aβ-induced neuronal damage,reduce Tau protein hyperphosphorylation,and suppress neuroinflammatory responses.The objective of this review is to provide a scientific and theoretical reference for the clinical prevention and treatment of AD and to inform the development of novel therapeutic agents.
