Data Mining Analysis of TCM Compound Patents for Treatment of Myocardial Infarction
10.19879/j.cnki.1005-5304.202408386
- VernacularTitle:中药复方专利治疗心肌梗死数据挖掘分析
- Author:
Fang GUAN
1
;
Yalong KANG
;
Juanjuan TAN
;
Hongfei QI
;
Yang LI
;
Man QIN
;
Ruonan WANG
;
Haifang WANG
Author Information
1. 陕西中医药大学,陕西省及咸阳市中西医结合心血管病防治重点实验室,陕西 咸阳 712000
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
national patent;
TCM compound;
data mining
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(3):58-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the medication law and compatibility characteristics of TCM compounds for the treatment of myocardial infarction in the national patent database.Methods TCM compounds for treating myocardial infarction were retrieved from CNIPA patent publication website.A prescription database was built using Excel 2019 software to statistically analyze the frequency of medicinal use and their properties,taste and meridian tropism;SPSS Modeler 18.0 software was used to analyze the association rules of drugs;a network of Chinese materia medica co-occurrence was constructed using Cytoscape 3.10.0,and systematic clustering analysis was performed on the Chinese materia medica in the core network.Results A total of 146 patents of TCM compounds were included,involved 440 kinds of Chinese materia medica.High frequency drugs included Salviea Miltiorrhizae Radix et Rhizoma,Chuanxiong Rhizoma,Angelicae Sinensis Radix,Glycyrrhizae Radix et Rhizoma,etc.The main property was warm,the main tastes were bitter,sweet and pungent,and the medicines mostly belongs to the liver meridian,heart meridian and spleen meridians.Commonly used medicinal pairs included Angelicae Sinensis Radix-Chuanxiong Rhizoma,Astragali Radix-Salviea Miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra-Angelicae Sinensis Radix,etc.Commonly used tripartite combinations included Paeoniae Radix Rubra-Chuanxiong Rhizoma-Angelicae Sinensis Radix,Carthami Flos-Angelicae Sinensis Radix-Chuanxiong Rhizoma,Carthami Flos-Chuanxiong Rhizoma-Angelicae Sinensis Radix,etc.Clustering analysis showed four types of combinations.Conclusion TCM compound patents for the treatment of myocardial infarction is based on promoting blood circulation,removing blood stasis,and relieving pain,while also using methods such as eliminating phlegm,tonifying qi,warming yang,and nourishing yin.It can provide references for clinical medication.
