Progress in regulatory role of macrophages in mucosal healing during in-flammatory bowel disease

VernacularTitle:巨噬细胞在炎性肠病黏膜愈合中的研究进展
Author: Keqi CHEN ¹ ; Yaobin LI ; Haoxian CHEN ; Yiming CUI ; Jian HONG ; Hui YUAN
Author Information

1. 暨南大学基础医学与公共卫生学院病理生理学系,广东广州 510632
Publication Type:Journal Article
Keywords: inflammatory bowel disease; intestinal macrophages; polarization; mucosal healing
From: Chinese Journal of Pathophysiology 2025;41(9):1807-1813
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease(IBD)is a chronic,nonspecific inflammatory condition of the intes-tine.However,its pathogenesis and molecular mechanisms remain elusive.The primary therapeutic goal for IBD is to achieve complete restoration of the intestinal mucosa.Despite various treatment strategies available in clinical practice,options to effectively promote mucosal healing remain limited.Macrophages play a pivotal role in maintaining intestinal ho-meostasis,modulating inflammatory responses,and facilitating mucosal healing.This review explores the significance and regulatory mechanisms of macrophages in intestinal mucosal healing,with particular emphasis on modulating macrophage phenotypic switching in the treatment of IBD.Furthermore,this review provides a theoretical basis for precision medicine in IBD treatment,highlighting valuable insights for more targeted therapeutic approaches.