Research Progress on the Application of Hot Melt Extrusion Technology in the Pharmaceutical Industry
10.3870/j.issn.1004-0781.2025.01.009
- VernacularTitle:热熔挤出技术在制药行业中的应用研究进展
- Author:
Bing YANG
1
;
Peng ZHAO
;
Siyi SHUAI
;
Xiaoxuan HONG
;
Conghui LI
;
Hui ZHANG
;
Nan LIU
;
Zengming WANG
;
Jia WEN
;
Aiping ZHENG
Author Information
1. 河北大学药学院,保定 071002;军事科学院军事医学研究院毒物药物研究所,北京 100850
- Publication Type:Journal Article
- Keywords:
Hot melt extrusion;
Pharmaceuticals;
Polymers;
Solid dispersions;
Drug formulation
- From:
Herald of Medicine
2025;44(1):73-80
- CountryChina
- Language:Chinese
-
Abstract:
Hot melt extrusion(HME)technology employs thermodynamic and kinetic principles to mix pharmaceutical polymers with crystalline drugs at high temperatures and extrude them,embedding drug molecules within the polymer matrix to form solid dispersions.Due to its solvent-free nature,capability for one-step processing,and support for continuous operation,HME has garnered significant attention in the pharmaceutical industry in recent years.This article introduced the basic principles and development history of HME technology and its marketed drugs.It reviewed the research progress of HME technology in improving drug solubility,masking taste,controlled release,targeted release,oral dispersible films,implant formulations,semi-solid formulations,and 3D printed formulations.Additionally,the article summarized the advantages and limitations of HME technology and provided an outlook on its future development.
