Comparison of the Efficacy of Intervertebral Fusion through Different Approaches Combined with Pedicle Screw Internal Fixation in the Treatment of Single-Segment Low-Grade Lumbar Spondylolisthesis:A Single-Center Retrospective Study of 87 Cases
10.13241/j.cnki.pmb.2025.15.011
- VernacularTitle:不同入路椎间融合联合椎弓根钉内固定术治疗单节段低度腰椎滑脱症的疗效比较:一项87例单中心回顾性研究
- Author:
Yan-ning LI
1
;
Shuai CHANG
1
;
Xiao-sheng YANG
1
;
Song-he LIU
1
;
Jin HUANG
1
Author Information
1. 中国医科大学航空总医院脊柱外科 北京 100012
- Publication Type:Journal Article
- Keywords:
Posterior lumbar interbody fusion;
Percutaneous endoscopic posterior lumbar interbody fusion;
Pedicle screw internal fixation;
Single-segment low-grade lumbar spondylolisthesis;
Efficacy
- From:
Progress in Modern Biomedicine
2025;25(15):2478-2486
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Based on a single-center retrospective study,to explore the efficacy of intervertebral fusion through different approaches combined with pedicle screw internal fixation in the treatment of single-segment low-grade lumbar spondylolisthesis.Methods:This study retrospectively analyzed the clinical data of 87 patients with single-segment low-grade lumbar spondylolisthesis who were treated in our hospital from January 2021 to August 2022,the cases were divided into Group A(41 cases)and Group B(46 cases)according to the differences in surgical methods.Group A received treatment with posterior lumbar interbody fusion(PLIF)combined with pedicle screw internal fixation,while Group B received treatment with percutaneous endoscopic posterior lumbar interbody fusion(PE-PLIF)combined with pedicle screw internal fixation.Both groups were followed up for two years.The Visual Analogue Scale(VAS)scores of the waist and legs,perioperative indicators,recovery of lumbar function[Japanese Orthopaedic Association(JOA)score,Oswestry Disability Index(ODI)score],and serum inflammatory mediators levels[interleukin-1α(IL-1α),transforming growth factor β1(TGF-β1),interleukin-6(IL-6)],the rate of lumbar interbody fusion,the rate of lumbar spondylolisthesis and the incidence of postoperative complications of the two groups were compared.Results:The operation time and the number of intraoperative X-ray fluoroscopy sessions in group B were both more than those in group A,while the hospital stay,the intraoperative blood loss and total incision length in Group B were all shorter than those in group A(P＜0.05).The VAS scores of the waist and legs in both groups decreased at 3 d after operation and the last follow-up(P＜0.05),and the VAS scores of the waist and legs in group B were lower than those in group A(P＜0.05).The ODI scores of both groups decreased at 3 d after operation and the last follow-up,and the ODI scores of group B were lower than those in group A;The JOA score increased,and the JOA scores of group B were all higher than those in group A(P＜0.05).Serum IL-1α,TGF-β1 and IL-6 levels in both groups decreased at 3 d and 7 d after operation,and serum IL-1α,TGF-β1 and IL-6 levels in group B were all lower than those in group A(P＜0.05).There was no statistically significant difference in the incidence of complications,the rate of lumbar interbody fusion,and the rate of lumbar spondylolisthesis between the two groups(P＞0.05).Conclusion:Compared with PLIF,PE-PLIF combined with pedicle screw internal fixation in the treatment of single-segment low-grade lumbar.spondylolisthesis,can better relieve the degree of pain of the waist and legs,improve lumbar dysfunction,regulate serum inflammatory mediators levels more effectively,and has higher safety and significant therapeutic efficacy.
