Correlation Analysis of MHR,NLR,PLR and Bone Density,Bone Metabolism Markers in Elderly Essential Hypertension with Osteoporosis Patients
10.13241/j.cnki.pmb.2025.15.009
- VernacularTitle:老年原发性高血压合并骨质疏松症患者MHR、NLR、PLR与骨密度和骨代谢标志物的相关性分析
- Author:
Ming-hui SONG
1
;
Xue-yan HUANG
;
Da-mei YE
;
Zhao-qiu WU
Author Information
1. 三明市第一医院风湿免疫科 福建三明 365000
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Osteoporosis;
Monocyte/high density lipoprotein ratio;
Bone density;
Neutrophil/lymphocyte ratio;
Platelet/lymphocyte ratio;
Bone metabolism markers
- From:
Progress in Modern Biomedicine
2025;25(15):2465-2471
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of monocyte/high density lipoprotein ratio(MHR),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and bone density,bone metabolism markers in elderly essential hypertension with osteoporosis(OP)patients.Methods:This study was a retrospective study,198 elderly essential hypertension patients who were admitted in our hospital from January 2022 to June 2024 were selected.According to the patient's bone mass test results,patients were divided into normal bone mass group(n=79),osteopenia group(n=68)and OP group(n=51).MHR,NLR,PLR,bone density(left hip,left femoral neck and lumbar spine L1-L4)and bone metabolism markers were compared among three groups,the correlation of MHR,NLR,PLR and bone density,bone metabolism markers were analyzed by Pearson correlation.Results:MHR,NLR,PLR in normal bone mass group,osteopenia group and OP group increased in turn(P＜0.05).The left hip,left femoral neck and lumbar spine L1-L4 bone density in normal bone mass group,osteopenia group,OP group decreased in turn(P＜0.05).25-hydroxyvitamin D[25(OH)D]in normal bone mass group,osteopenia group and OP group decreased in turn,alkaline phosphatase(ALP)and parathyroid hormone(PTH)increased in turn(P＜0.05).MHR,NLR and PLR were negatively correlated with left hip bone density,left femoral neck bone density,lumbar spine L1-L4 bone density,25(OH)D and positively correlated with PTH and ALP(P＜0.05).Conclusion:The increase of MHR,NLR and PLR in elderly essential hypertension with OP patients can affect bone mineral density and bone metabolism.
