Exploration on the Biological Basis of Phlegm-Dampness Syndrome in Coronary Heart Disease Combined with Atrial Fibrillation Based on 4D-DIA
10.19879/j.cnki.1005-5304.202406560
- VernacularTitle:基于4D-DIA蛋白质组学探析冠心病合并房颤痰浊证生物学基础
- Author:
Chenglin DUAN
1
;
Yihang DU
;
Yuanhui HU
Author Information
1. 北京中医药大学,北京 100029;中国中医科学院广安门医院,北京 100053
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
atrial fibrillation;
phlegm-dampness syndrome;
proteomics
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(2):149-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differentially expressed serum proteins between phlegm-dampness syndrome and non-phlegm-dampness syndrome in patients with coronary heart disease(CHD)combined with atrial fibrillation(AF);To explore the biological basis underlying this comorbidity.Methods Totally 20 patients with phlegm-dampness syndrome and non-phlegm-dampness syndrome of CHD-AF were included,with 10 cases in each group.4D data-independent acquisition(DIA)proteomics was employed for protein expression profiling.Differential proteins were screened based on criteria and protein interaction network analysis was performed to identify key differential proteins between the two groups.GO and KEGG pathway enrichment analyses were conducted on the key differential proteins to elucidate the biological basis of phlegm-dampness syndrome in CHD-AF.Results A total of 27 differential proteins were identified based on the screening criteria,including 2 up-regulated and 25 down-regulated proteins.Protein interaction network analysis revealed 10 key differential proteins.GO and KEGG pathway enrichment analyses suggested that phlegm-dampness syndrome in CHD-AF was primarily associated with inflammatory responses,oxidative stress and dysregulation of fluid metabolism.Conclusion Serum protein expression profiles differed between phlegm-dampness and non-phlegm-dampness syndromes in CHD-AF patients.The biological basis may be mainly related to inflammatory responses,oxidative stress and dysregulation of fluid metabolism.
