Clinical Study on the Combination of Yugu Ju Detergent and Fusidic Acid Cream for the Repair of Chronic Wounds Caused by Staphylococcus Aureus Infection
10.13241/j.cnki.pmb.2025.15.004
- VernacularTitle:愈骨疽洗剂联合夫西地酸乳膏对金黄色葡萄球菌感染慢性创面修复的临床研究
- Author:
Ran-dong PENG
1
;
Jun ZHAO
;
Wen-bo YANG
;
Jun-wei BI
;
Hong-xi LIU
Author Information
1. 甘肃省中医院骨髓炎科 甘肃兰州 730050
- Publication Type:Journal Article
- Keywords:
Yugu Ju Detergent;
Fusidic acid cream;
Chronic wound;
Staphylococcus aureus
- From:
Progress in Modern Biomedicine
2025;25(15):2431-2437
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Observation of the therapeutic effect of Yugu Ju detergent combined with fusidic acid cream on the repair of wounds infected with Staphylococcus aureus,as well as its impact on serum inflammatory markers TNF-α,IL-6,IL-1β,oxidative stress markers MDA,ROS,SOD and Nrf2 levels.Methods:96 patients with skin defects and SA U infection caused by trauma admitted to the hospital from June 2021 to December 2023 were randomly divided into a control group and an observation group.Both groups were treated with debridement,while the control group was treated with external application of fusidic acid cream.The treatment group received external washing with Yugu Ju detergent in addition to the control group.One course of treatment lasted for 7 days,with three consecutive courses of treatment.Observe the wound healing rate,bacterial clearance rate,and changes in TNF-α,IL-6,IL-1β,SOD,MDA,ROS,and Nrf2 before and after treatment to evaluate clinical efficacy and safety.Results:The total clinical effective rate of the observation group after treatment was 93.75％(45/48),while that of the control group was 75％(36/48).The observation group was significantly better than the control group(P＜0.05);The wound healing rate and bacterial clearance rate of the observation group at each time point after treatment were higher than those of the control group(P＜0.05);After treatment,the Nrf2 and SOD values in the observation group were higher than those in the control group,while the TNF-α,IL-6,IL-1β,MDA,and ROS values were lower than those in the control group(P＜0.05).No adverse reactions occurred during the treatment of both groups.Conclusion:The combination of Yugu Ju detergent and Fusidic acid cream can inhibit SA U and promote the healing of infectious wounds,which may be related to the activation of Nrf2 expression to inhibit oxidative stress and inflammatory response.It is safe and effective,and worthy of promotion and application.
