Melatonin alleviated acute myocardial infarction by inhibiting ferroptosis
10.3969/j.issn.1000-4718.2025.09.002
- VernacularTitle:褪黑素通过抑制铁死亡减轻急性心肌梗死
- Author:
Xiaohui HUANG
1
;
Weixing WEN
;
Peng CHEN
;
Weiwen LI
;
Jiahuan LI
;
Yue CAO
;
Yunzhao HU
;
Yuli HUANG
Author Information
1. 南方医科大学第八附属医院(佛山市顺德区第一人民医院)心血管内科,广东 佛山 528308;南方医科大学第八附属(佛山市顺德区第一人民医院)医学研究中心,广东 佛山 528308
- Publication Type:Journal Article
- Keywords:
acute myocardial infarction;
melatonin;
ferroptosis;
cardioprotection
- From:
Chinese Journal of Pathophysiology
2025;41(9):1674-1684
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate whether melatonin can ameliorate acute myocardial infarction(AMI)by in-hibiting ferroptosis.METHODS:H9C2 cells were cultured in AnaeroPack system with low sugar and serum-free medium for 10 h to construct a cell model of AMI.Then cells were treated with melatonin and ferroptosis inducer erastin.The cell activity,reactive oxygen species(ROS),lipid peroxidation,mitochondrial membrane potential(MMP),and ferroptosis related protein expression were detected.A rat model of AMI induced by isoprenaline(ISO)injection was established to evaluate the effects of melatonin,in which the myocardial infarction size,cardiac injury,pathological changes,oxidative stress,iron ion and ferroptosis related protein expression were examined.RESULTS:Melatonin decreased the oxidative stress,lipid peroxidation and expression of ferroptosis protein in cardiomyocytes induced by hypoxia,but these effects could be impeded by the ferroptosis inducer erastin.Furthermore,in vivo experiments,we also found that melatonin im-proved the myocardial infarction size,cardiac injury,pathological changes,oxidative stress,and alleviated iron ion accu-mulation and ferroptosis.CONCLUSION:The cardioprotective effects of melatonin in AMI are associated with the inhi-bition of ferroptosis.
