Research Progress of Chinese Materia Medica in the Intervention of Sepsis by Targeting IκB/NF-κB Signaling Pathway
10.19879/j.cnki.1005-5304.202312520
- VernacularTitle:中药靶向IκB/NF-κB信号通路干预脓毒症研究进展
- Author:
Liangyukun ZHENG
1
;
Guanglan XU
;
Guangyao WANG
Author Information
1. 广西中医药大学研究生院,广西 南宁 530001
- Publication Type:Journal Article
- Keywords:
sepsis;
inflammation;
IκB/NF-κB signaling pathway;
Chinese materia medica;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(2):184-190
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a common complication in patients with infection,severe trauma and burns.The inflammatory process mediated by IκB/NF-κB in sepsis is considered a target of new anti-inflammatory drugs.Chinese materia medica intervention in sepsis has the characteristics of multi-component,multi-target and minimal adverse reactions.This article summarized the relevant research on the intervention of Chinese materia medica targeting the IκB/NF-κB signaling pathway in sepsis,and concluded the mechanism of TCM monomers and their extracts,TCM prescriptions and preparations in reducing inflammation and oxidative stress,regulating immunity and protecting important organs from damage in sepsis by targeting the IκB/NF-κB signaling pathway.It could provide references for the treatment of sepsis with Chinese materia medica.
