Research progress in roles of AGE-RAGE axis in occurrence and development of metabolism-related diseases and its intervention
10.3867/j.issn.1000-3002.2024.12.007
- VernacularTitle:AGE-RAGE轴在代谢相关疾病发生发展中的作用及其干预策略研究进展
- Author:
Cuimei ZHAO
1
;
Yajing WU
;
Yingran LI
;
Xiuzhen LONG
;
Xun ZHOU
;
Wenyuan ZHANG
Author Information
1. 遵义医科大学药学院,贵州遵义563006;中山市人民医院药学部,广东中山 528403
- Publication Type:Journal Article
- Keywords:
advanced glycation end products;
receptor;
metabolism-related diseases;
hypertension;
diabetes;
atherosclerosis
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(12):952-958
- CountryChina
- Language:Chinese
-
Abstract:
Metabolism-related diseases are chronic diseases caused by genetic and environmental factors.The symptoms include insulin resistance,abnormal blood glucose and lipid levels,and elevated blood pressure.This type of illness has become a major threat to human health,and there is an urgent need to find effective treatments.Advanced glycation end products (AGE) are a group of complex and heterogeneous compounds that result from reduced interactions between the carbonyl groups of sugar and the free amino groups of proteins,lipids,and nucleic acids.Increasing evidence shows that AGE and its receptor (RAGE) are involved in the occurrence and development of such metabolism-related diseases as hypertension,diabetes,and atherosclerosis.AGE can have adverse effects on tissues through non-receptor and receptor-mediated mechanisms.In the receptor-mediated mechanism,AGE interacts with RAGE to increase the production of oxygen free radicals and activate NF-κB so that more pro-inflammatory cells are expressed and released,leading to cell damage.This article reviews the research progress in interventions with AGE and RAGE in the treatment of hypertension,diabetes,and atherosclerosis from a metabolic perspective in the hope of exploring the potential of AGE and RAGE as therapeutic targets for metabolism-related diseases.
