Research progress in mechanisms of methamphetamine-induced neurodegenerative diseases and related therapeutic strategies
10.3867/j.issn.1000-3002.2024.12.008
- VernacularTitle:甲基苯丙胺滥用诱发神经退行性疾病的机制及相关治疗策略的研究进展
- Author:
Xiong LI
1
;
Genmeng YANG
1
;
He YAN
1
;
Jiameng DING
1
;
Shijun HONG
1
;
Dongxian ZHANG
1
Author Information
1. 昆明医科大学法医学院,国家卫健委毒品依赖和戒治重点实验室,云南昆明 650500
- Publication Type:Journal Article
- Keywords:
methamphetamine;
neurotoxicity;
Alzheimer disease;
Parkinson disease;
Huntington disease;
medication
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(12):959-966
- CountryChina
- Language:Chinese
-
Abstract:
Methamphetamine (METH) is a highly addictive synthetic psychoactive drug that is often abused as a psychostimulant.Chronic exposure to METH induces neurotoxic effects through oxidative stress,impairment of mitochondrial function,activation of astrocytes and microglia,and amino acid excitability.METH abuse increases the chance of developing neurodegenerative diseases such as Alzheimer's disease,Parkinson's disease,Huntington's disease.However,the mechanism behind METH-induced neurotoxicity remains incompletely understood.So far,there is no specific treatment for METH-induced neurotoxicity.This paper reviews some of the potential mechanisms of METH-induced neurotoxicity in recent years,such as neuroinflammation,glutamatergic excitotoxicity,oxidative stress,and mitochondrial toxicity,and discusses the current therapeutic strategies related to mitigating the neurotoxic effects of METH in the brain through different pathways.
