Research progress on glucose metabolism reprogramming of tumor-associated macrophages in gastric cancer
10.3969/j.issn.1672-8467.2025.05.013
- VernacularTitle:肿瘤相关巨噬细胞的糖代谢重编程在胃癌中的研究进展
- Author:
Yun-tian DENG
1
;
Yuan GU
1
;
Yi-hong SUN
1
;
Hong-shan WANG
1
Author Information
1. 复旦大学附属中山医院胃肠外科 上海 200032
- Publication Type:Journal Article
- Keywords:
gastric cancer;
glucose metabolism;
macrophage
- From:
Fudan University Journal of Medical Sciences
2025;52(5):717-723
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages(TAMs)are one of the key components of the tumor microenvironment(TME)in gastric cancer.Glucose metabolism reprogramming significantly impacts TAMs'polarization and immune functions,thereby regulating the onset and the progression of gastric cancer.This review summarizes glucose metabolism reprogramming in TAMs'polarization and explores its role in gastric cancer-related TAMs through aspects such as signaling regulation,transcription factors,and epigenetic modifications.This review aims to deepen the understanding of TAMs'role in gastric cancer progression and offer new perspectives for the immunotherapy in gastric cancer.
