Triglyceride-glucose index in evaluating metabolic differences and its role in predicting all-cause mortality in patients with heart failure
10.3969/j.issn.1009-0126.2025.02.007
- VernacularTitle:三酰甘油葡萄糖指数在心力衰竭代谢差异及全因死亡预测中的作用
- Author:
Qingqing ZHANG
1
;
Xiangwei DING
;
Guoyu WANG
;
Si SUN
;
Suyun JIANG
;
Jing ZHENG
;
Peng GAO
;
Yucheng WU
Author Information
1. 225300 南京医科大学附属泰州人民医院(泰州市人民医院)泛血管疾病管理中心
- Publication Type:Journal Article
- Keywords:
heart failure;
risk factors;
retrospective studies;
prognosis
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(2):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare TyG index between the patients with CHF and ADHF to eluci-date the metabolic difference between these two stages.Methods A total of 1156 HF patients ad-mitted in Taizhou People's Hospital between January 2020 and December 2022 were enrolled,and according to 2021 ESC Guidelines for Diagnosis and Treatment of Acute and Chronic Heart Fail-ure,they were divided into CHF group(365 cases)and ADHF group(791 cases).The clinical da-ta,results of laboratory tests,and cardiovascular history were collected,and TyG index was calcu-lated.All-cause death outcome was observed in ADHF patients during a follow-up of 1 year.Results The TyG index was significantly lower in the ADHF group than the CHF group[8.27(7.99,8.62)vs 8.35(8.04,8.75),P=0.001].In the ADHF group,the TyG index was positively correlated with SBP,DBP,TC,TG,LDL-C,FPG,HbA1c,BMI,and LVEF,and negatively with age(P＜0.01).In the CHF group,the index was positively correlated with DBP,TC,TG,LDL-C,FPG,BMI,and HbA1c,and negatively with age(P＜0.05,P＜0.01).Both univariate and multiva-riate logistic regression analyses indicated that the TyG index was a protective factor for ADHF(OR=0.647,95％CI:0.503～0.832,P=0.001;OR=0.694,95％CI:0.536～0.898,P=0.005).Multivariate logistic regression analysis showed that the index in ADHF patients was a protective factor for one-year all-cause mortality(OR=0.483,95％CI:0.254-0.916;P=0.026).Conclusion TyG index might be regarded as an important marker for assessing the metabolic status in HF patients and predicting the prognosis in ADHF patients.
