Based on the Theory of"Earth stagnation,Wood Depression",the Mechanism Connotation of Intestinal Flora-Bile Acid Metabolism Axis of Type 2 Diabetes Mellitus was Discussed
10.11842/wst.20230422003
- VernacularTitle:基于肠道菌群-胆汁酸代谢轴探讨T2DM"土壅木郁"病机的生物学内涵
- Author:
Shuang ZHANG
1
;
Pin LI
;
Jiren AN
;
Yufeng YANG
;
Yan SHI
Author Information
1. 辽宁中医药大学 沈阳 110847
- Publication Type:Journal Article
- Keywords:
Intestinal flora;
Bile acids;
T2DM;
Earth stagnation wood depression;
Restraining wood and hilling earth
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2024;26(10):2668-2675
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease with a high prevalence of high prevalence,mainly manifested by hyperglycemia,insulin secretion or insulin resistance,often complicated by hypertension,hyperlipidemia and other metabolic abnormalities.In recent years,the association between intestinal flora,bile acids and T2DM has been a hot topic in clinical research.Traditional Chinese medicine believes that the spleen and stomach belong to soil,liver and gallbladder belong to wood,spleen soil stagnation,soil internal heat,affecting the drainage of liver wood;The liver wood is staggered,Liver qi stagnation,the middle scorch is suppressed,and finally the spleen is stagnant,which is the image of"earth stagnation,wood depression".Earth stagnation and wood depression are the cause and effect of each other,which is the theoretical basis for the occurrence and development of T2DM,and earth stagnation cannot transport water valley to nourish liver wood,and the liver loses nourishment,resulting in liver qi loss in drainage,qi depression and fire injury yin,burning lungs,robbing gastric juice,consuming kidney water,and inducing thirst quenching.From the perspective of modern medicine and biotechnology,the intestinal flora-bile acid metabolic axis is used as the starting point to explain the scientific connotation of the theory of soil wood.Intestinal flora disorder is an important biological basis of the soil,the spleen and soil are stagnant,the water valley does not change,affecting the body's digestion,immunity,lipids and other aspects,resulting in intestinal flora disorders.Abnormal bile acid metabolism is an important microscopic embodiment of wood depression,liver loss and drainage,gas engine lifting and lowering abnormalities,resulting in bile depression,bile acid metabolism secretion abnormal.The intestinal microbiota-bile acid metabolism axis regulates glucose metabolism and glucose homeostasis by affecting the structural composition and diversity of intestinal flora and bile acid pool composition in T2DM patients,thereby affecting the development process of diabetes.Therefore,this paper discusses the biological connotation of T2DM"earth stagnation,wood depression"from the perspective of intestinal microbiota-bile acid metabolic axis,better explains the scientific nature of T2DM soil woody depression mechanism,and provides new clinical ideas and theoretical basis for the prevention and treatment of T2DM.
