Effect of Echinacea purpurea extract on digestive ability and intestinal barrier function of Bamei ternary pigs
10.16303/j.cnki.1005-4545.2025.07.22
- VernacularTitle:紫锥菊提取物对八眉三元猪消化能力和肠道屏障功能的影响
- Author:
Zixin CHEN
1
;
Hua WU
1
;
Wensheng WANG
1
;
Jiayi LIU
1
;
Jiewei SHEN
1
;
Long LI
1
;
Guohong ZHAO
1
;
Shulei MA
1
Author Information
1. 青海大学农牧学院,青海西宁 810016
- Publication Type:Journal Article
- Keywords:
Echinacea purpurea extract;
Bamei ternary pigs;
digestive capacity;
immune function;
antioxidant capacity;
intestinal barrier
- From:
Chinese Journal of Veterinary Science
2025;45(7):1525-1534
- CountryChina
- Language:Chinese
-
Abstract:
The aim of the experiment was to study the effects of Echinacea purpurea extract on the digestive ability,immune function and intestinal barrier of the Bamei ternary pigs.Forty-eight healthy pigs of 50 days old were randomly divided into four groups,each with three replicates and four pigs in each replicate.The control group(CON)was fed a basal diet,and the experimental group was divided into 5 g/kg(T1),10 g/kg(T2)and 15 g/kg(T3)of Echinacea extract in the basal diet.The pre-test period was 5 days and the main test period was 35 days with free feeding and drinking during the test period.The results showed that:There was no significant effect on the apparent digestibility of nutrients and jejunum morphology in the test group compared to the CON group(P＞0.05).Amylase and trypsin activities were significantly higher in the experimental group and lipase activities were significantly higher in T2 and T3 groups compared to CON group(P＜0.05).GSH,CAT and T-AOC activities were significantly higher in the experimental group compared to CON group(P＜0.05).In comparison with CON group,the levels of IL-1 and IL-6 were significantly lower in the experimental group(P＜0.05),and the levels of TNF-α were significantly lower in the T2 and T3 groups(P＜0.05);and the levels of IL-10 were signifi-cantly higher in the T3 group(P＜0.05).The mRNA and protein expression levels of TLR4,MyD88,TRAF6,and NF-κB were significantly lower in the experimental group(P＜0.05).The mRNA and protein expression levels of CLDN-1,OCLN and ZO-1 were significantly increased in the test group(P＜0.05).The results between the test groups showed that the protein expression levels of CLDN-1 and OCLN were significantly increased in the T3 group compared with the T1 group(P＜0.05).In conclusion,the addition of Echinacea extract to the ration can,to a certain ex-tent,improve the digestive ability,balance the immune ability,and improve the intestinal barrier function of the Bamei ternary pigs,thus promoting the intestinal health of pigs.
