Research progress on the changes of host TLRs signaling pathway induced by Japa-nese encephalitis virus infection
- VernacularTitle:乙型脑炎病毒感染引起宿主TLRs信号通路变化的研究进展
- Author:
Wenwen HU
1
;
Deyuan TANG
1
;
Zhiyong ZENG
1
;
Bin WANG
1
;
Min ZHOU
1
;
Yinming MAO
1
;
Piao ZHOU
1
;
Song HE
1
;
Li ZHANG
1
;
Fangxin GAO
1
Author Information
- Publication Type:Journal Article
- Keywords: JEV; infection; Toll-like receptor; signal transduction
- From: Chinese Journal of Veterinary Science 2025;45(7):1553-1562
- CountryChina
- Language:Chinese
- Abstract: Japanese encephalitis virus(JEV)belongs to the genus Flavivirus and the family Flavi-viridae,and is classified as a single-stranded,positive-sense RNA virus.The disease known as Japa-nese encephalitis(JE),which results from JEV infection,is a viral zoonosis that is prevalent worldwide and poses a significant public health concern.JEV infection activates a variety of signa-ling pathways,leading to a series of changes that are crucial to the virus's pathogenesis.Among these pathways,Toll-like receptors(TLRs)are particularly significant,and their diverse range and complex signal transduction mechanisms present substantial challenges for the prevention and con-trol of JEV.Currently,there is no specific treatment for JEV.Although some vaccines have been developed to prevent JE,eradicating JEV remains difficult due to its zoonotic transmission cycle and the limited efficacy of the available vaccines.This article reviews the alterations in various TLR signaling pathways induced by JEV infection in the host,aiming to provide insights into the patho-genic mechanisms of JEV and to identify potential new antiviral targets.
