Research progress of bone morphogenetic protein signaling pathway in central nervous system
10.3969/j.issn.1006-5725.2025.01.023
- VernacularTitle:骨形态发生蛋白信号通路在中枢神经系统中的研究进展
- Author:
Yin-gying GAN
1
;
Min HU
;
Shuya CUI
;
Zhi CHAI
;
Huijie FAN
Author Information
1. 山西中医药大学多发性硬化益气活血重点研究室/神经生物学研究中心(山西 晋中 030619)
- Publication Type:Journal Article
- Keywords:
BMP signaling pathway;
central nervous system;
spinal cord injuries;
neural tube defects
- From:
The Journal of Practical Medicine
2025;41(1):141-145
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic proteins are a large subclass of the transforming growth factor β family,and Their signaling pathways are mainly classified into two kinds based on whether they depend on Smad protein to mediate or not.BMP signaling pathways are involved in regulating cell proliferation and differentiation,as well as the formation and development of multiple tissues and organs.Recent studies have shown that BMP signaling path-ways mainly promote the differentiation and growth of neurons and astrocytes,and are closely related to the my-elination of oligodendrocytes.In addition,BMP signaling pathways also play an important role in the occurrence of central nervous system diseases,such as spinal cord injuries,multiple sclerosis,neural tube defects,and Parkin-son's disease.This article reviews the BMP signaling pathways'composition,transduction mechanism and their role in the central nervous system and related diseases,in order to provide more potential ideas for basic research and clinical treatment of central nervous system diseases.
