Effects of hyperbaric oxygen combined with monosialotetrahexosyl ganglioside on spinal cord injury and on galectin-3 and TGF-β1
10.3760/cma.j.cn311847-20201229-00481
- VernacularTitle:高压氧联合单唾液酸四己糖神经节苷脂治疗脊髓损伤的疗效及对galectin-3、TGF-β1的影响
- Author:
Hua LI
1
;
Jiali XING
;
Fake MENG
;
Kaibo SU
Author Information
1. 265600 山东省烟台，蓬莱市人民医院外五科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Monosialotetrahexosyl ganglioside;
Spinal cord injury;
Galectin-3;
TGF-β1
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(3):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of hyperbaric oxygen combined with monosialotetrahexosyl ganglioside on spinal cord injury and on galectin-3 and transforming growth factor-β1 (TGF-β1).Methods:A total of 116 patients with spinal cord injury treated in Yantai Penglai People’s Hospital from July 2018 to August 2020 were selected and divided into combination group ( n=59) and single-drug group ( n=57) according to the treatment method. The single-drug group was treated with monosialotetrahexosyl ganglioside, and the combination group was given hyperbaric oxygen on the basis of the treatment in the single-drug group. The clinical efficacy, the levels of serum galectin-3 and TGF-β1, motor and sensory scores, the recovery time of spinal cord function, and the incidence of adverse drug reactions (ADR) were compared between the two groups. Results:After treatment, the total effective rate of the combination group (88.14%) was significantly higher than that of the single-drug group (68.42%), and the difference was statistically significant ( P<0.01). After treatment, the levels of serum galectin-3 and TGF-β1 in the two groups were significantly decreased compared with the levels before treatment, and the levels of the combination group were significantly lower than those of the single-drug group, with statistically significant differences ( P<0.05 or P<0.01). After treatment, the motor and sensory scores of the two groups were significantly increased compared with the scores before treatment, and the scores of the combination group were significantly higher than those of the single-drug group, with statistically significant differences ( P<0.01). The recovery time periods of sphincter function, the 2/5 grade muscle strength, and unassisted walking in the combination group were significantly shorter than those of the single-drug group, with statistically significant differences ( P<0.01). There was no statistically significant difference in the incidence of ADR between the two groups ( P>0.05). Conclusion:The treatment of hyperbaric oxygen combined with monosialotetrahexosyl ganglioside has a significant therapeutic effect on the patients with spinal cord injury, and can effectively improve the levels of serum galectin-3 and TGF-β1 in patients.
