Research progress on the correlation between carbohydrate antigen 19-9 and pseudomyxoma peritonei
10.12354/j.issn.1000-8179.2025.20250646
- VernacularTitle:CA19-9与腹膜假黏液瘤的相关性研究进展
- Author:
Wei TIAN
1
;
Zhao QIDI
1
;
Li YAN
1
Author Information
1. 清华大学北京清华长庚医院腹膜肿瘤科(北京市 102218)
- Publication Type:Journal Article
- Keywords:
pseudomyxoma peritonei(PMP);
carbohydrate antigen 19-9(CA19-9);
molecular biology;
tumor markers
- From:
Chinese Journal of Clinical Oncology
2025;52(13):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Pseudomyxoma peritonei(PMP)is a rare malignant peritoneal syndrome characterized by progressive intra-abdominal accumu-lation and redistribution of gelatinous tumor-derived mucins.This disease primarily originates in the appendix or ovaries and exhibits distinct biological behavior and clinicopathological features.Carbohydrate antigen 19-9(CA19-9),a critical tumor biomarker,is significantly correl-ated with the development and progression of PMP.This association renders CA19-9 increasingly valuable in clinical diagnosis and treat-ment.Furthermore,molecular biological characteristics of CA19-9,including structural properties,biosynthetic pathways,and mechanisms in mediating tumor metastasis,are systematically elaborated.These findings highlight the association between CA19-9 expression and PMP pathological grading,clinical prognosis,and therapeutic response monitoring.Additionally,the study thoroughly analyzed the synergistic role of CA19-9,alongside other tumor biomarkers,in PMP management.Based on current evidence,future research directions are proposed.These include the potential application of CA19-9 in early PMP diagnosis,its therapeutic utility as a molecular target,and the exploration of CA19-9-associated signaling pathways in PMP pathogenesis.The insights provide novel perspectives and a theoretical foundation for PMP-based precision medicine.
