Research progress in ultrasound combined with drug-loaded microbubbles to improve tumor microenvironment and enhance immunotherapy efficacy
10.12354/j.issn.1000-8179.2025.20241446
- VernacularTitle:超声联合载药微泡改善肿瘤微环境增强免疫疗效的研究进展
- Author:
Xu SHIJIN
1
;
Zhang QIAOYU
;
Xu QIAO
;
Liu YUN
Author Information
1. 三峡大学第一临床医学院,宜昌市中心人民医院超声科(湖北省 宜昌市 443003);三峡大学肿瘤微环境与免疫治疗湖北省重点实验室
- Publication Type:Journal Article
- Keywords:
ultrasound;
microbubble;
tumor microenvironment(TME);
immune
- From:
Chinese Journal of Clinical Oncology
2025;52(2):92-96
- CountryChina
- Language:Chinese
-
Abstract:
Immunotherapy has recently shown significant potential in treating malignant tumors.However,the immunosuppressive nature of the tumor microenvironment(TME)limits the number of patients who benefit from this approach.Combining ultrasound with drug-loaded microbubble technology can directly induce tumor cell death through cavitation and pore-forming effects;this promotes tumor anti-gen presentation and enhances immune recognition of these antigens.This strategy also modulates the immunosuppressive state of the tu-mor microenvironment,making it more conducive to an effective immune response.It also normalizes blood vessels and reduces interstitial fluid pressure within the tumor,as well as helps therapeutic agents or genes to penetrate tumor tissues,thereby enhancing overall immune efficacy.This review examines the use of low-intensity ultrasound combined with drug-loaded microbubbles to improve the tumor microen-vironment and boost tumor immune responses.
